IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a recombinant analogue of IGF-1 in which the native sequence has been modified to include an N-terminal 13-amino acid extension and an Arg substitution at position 3, significantly reducing its binding to IGF-binding proteins (IGFBPs). This modification extends its plasma half-life from minutes to several hours and increases its bioavailability and potency relative to native IGF-1. IGF-1 LR3 signals through the IGF-1 receptor (IGF-1R) to promote cellular growth, proliferation, and differentiation across muscle, bone, and other tissues. It is widely studied in the context of muscle hypertrophy, recovery acceleration, and anabolic research.