SLU-PP-332

SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ), a family of nuclear receptors that regulate the transcription of genes involved in mitochondrial biogenesis, oxidative metabolism, and exercise adaptation. By activating ERR signaling, SLU-PP-332 has been shown in preclinical research to induce gene expression changes that mimic the effects of endurance exercise — increasing mitochondrial density, enhancing fatty acid oxidation, and improving aerobic capacity in sedentary animal models. It is of significant interest as a potential exercise mimetic and in research on metabolic disease and aging.