GHRP-6 is a synthetic hexapeptide growth hormone secretagogue that acts as a potent agonist at the ghrelin receptor (GHS-R1a), stimulating robust GH release from the anterior pituitary. It is one of the first-generation GHRPs and has been extensively studied for its ability to amplify GH pulsatility, promote lean mass accrual, and support recovery. In addition to GH release, GHRP-6 is notable for its appetite-stimulating properties via central ghrelin receptor activation — a mechanism of research interest distinct from newer, more selective secretagogues. It is often used alongside a GHRH analogue to maximize GH output.